Liver Cell-Selective Targeting Using Glycosylated Liposomes
نویسندگان
چکیده
منابع مشابه
Targeting liposomes and lipoplexes to cells in the liver.
The liver harbors several populations of cells that play a crucial role in a number of vital functions of the body. In addition, this organ is often a primary site of metastatic tumor growth often leading to catastrophic consequences for the patient. We have studied the potential of lipid-based drug carriers to deliver therapeutically active agents specifically to the following four liver-assoc...
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Tumor-specific targeting is a critical goal in the research area of liposomal drug delivery. Identification of the specific interactions between ligands and target tumor cells is a principle prerequisite in achieving this goal. Generally, tumor cells aberrantly express tumor-associated antigens that can be utilized as appropriate target molecules. Monoclonal antibodies against tumor-associated ...
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Hepatocellular carcinomas are well-vascularized tumors; the endothelial cells in these tumors have a specific phenotype. Our aim was to develop a new approach for tumor-specific drug delivery with monoclonal antibody targeting of endothelial ligands. CD146, a molecule expressed on the endothelial surface of hepatocellular carcinoma, was identified as a promising candidate for targeting. In the ...
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CD44 receptor protein is found to be overexpressed by many tumors and is identified as one of the most common cancer stem cell surface markers including tumors affecting colon, breast, pancreas, and head and neck, making this an attractive receptor for therapeutic targeting. In this study, 2'-F-pyrimidine-containing RNA aptamer (Apt1), previously selected against CD44, was successfully conjugat...
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ژورنال
عنوان ژورنال: Drug Metabolism and Pharmacokinetics
سال: 1999
ISSN: 0916-1139
DOI: 10.2133/dmpk.14.supplement_116